Ocular Immune Privilege in the Year 2010: Ocular Immune Privilege and Uveitis
نویسندگان
چکیده
منابع مشابه
Ocular immune privilege
The eye attempts to limit local immune and inflammatory responses to preserve vision. This phenomenon, known as ocular immune privilege, is mediated by a combination of local and systemic mechanisms. While immune privilege is believed to protect the eye from day-to-day inflammatory insults, it is not absolute and its mechanisms are still incompletely understood.
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Allografts are afforded a level of protection from rejection within immune-privileged tissues. Immune-privileged tissues involve mechanisms that suppress inflammation and promote immune tolerance. There are anatomical features, soluble factors, membrane-associated proteins, and alternative antigen-presenting cells (APC) that contribute to allograft survival in the immune-privileged tissue. This...
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JL he eye and the immune system represent discrete organ systems in vertebrates. Each possesses a unique and vital function that ensures the viability of the host, and loss of either or both brings disease and death. For many years, it has been known that the eye and the immune system are joined in a curious phenomenon called "immune privilege." This phenomenon was first described experimentall...
متن کاملEffects of experimental ocular inflammation on ocular immune privilege.
PURPOSE To determine whether the inflammation of endotoxin-induced uveitis (EIU) and experimental autoimmune uveoretinitis (EAU) alters key in vivo and in vitro parameters of ocular immune privilege. METHODS For EIU induction, C3H/HeN mice received 200 microg lipopolysaccharide (LPS). For EAU induction, B10.A mice were immunized with 50 microg interphotoreceptor retinoid-binding protein (IRBP...
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Evidence of immune privilege in the eye was recorded almost 140 years ago, yet interest in immune privilege languished for almost a century. However, the past 35 years have witnessed a plethora of research and a rekindled interest in the mechanisms responsible for immune privilege in the anterior chamber of the eye. This research has demonstrated that multiple anatomical, structural, physiologi...
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ژورنال
عنوان ژورنال: Ocular Immunology and Inflammation
سال: 2010
ISSN: 0927-3948,1744-5078
DOI: 10.3109/09273948.2010.525730